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Glycoside-O-4
 |
Source | Am J Physiol Cell Physiol (2015). Figure 5. Glycoside-O-4 |
| Method | CG induced internalization | |
| Cell Lines | H1299 cells | |
| Concentrations | 30 and 100 nM | |
| Incubation Time | 6 h | |
| Results | As can be seen from Fig. 5, α1, with a KD for ouabain somewhat lower than that of α2, indeed undergoes a higher level of internalization than α2 in response to ouabain, particularly at the lower concentration. |
| Cell Experiment | |
|---|---|
| Cell lines | A549 cells |
| Preparation method | The effect of cardiac glycosides on cell proliferation and survival has been linked to their ability to generate multiple signals after the interaction with Na/K-ATPase; in particular, Ras-Raf-MEKERK1/ 2 cascade, generation of mitochondrial reactive oxygen species (ROS) and JNK activation. |
| Concentrations | 100 nM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Six-week-old female BALB/c nu/nu mice |
| Formulation | |
| Dosages | 25 mg/kg |
| Administration | i.v. |
| Molecular Weight | 802.96 |
| Formula | C39H62O15S |
| CAS Number | 94898-61-0 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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