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Glutaminase C-IN-1 (Compound 968) is an allosteric inhibitor of Glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts.
| Molecular Weight | 475.42 |
| Formula | C27H27BrN2O |
| CAS Number | 311795-38-7 |
| Form | Solid |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Glutaminase Products |
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| BPTES
BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM. |
| GK921
GK921 is a transglutaminase 2 (TGase 2) inhibitor. |
| 6-Diazo-5-oxo-L-norleucine
6-Diazo-5-oxo-L-norleucine (Diazooxonorleucine, L-6-Diazo-5-oxonorleucine, DON) is an antibiotic isolated from Streptomyces, an antagonist of glutaminase with an IC50 value of about 1 mM for cKGA (renal glutamine). 6-Diazo-5-oxo-L-norleucine has analgesic, antibacterial, antiviral and anti-cancer properties. |
| L-Albizziin
L-albizziin (L-alpha-amino-beta-ureidopropionic acid) is a potent inhibitor of glutamase. L-albizziin interferes with the utilisation of L-glutamine by the Debaryomyces spp. enzyme probably in a competitive and reversible manner since L-albizziin is also a substrate of the enzyme. |
| Cystamine
Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. |
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