Free shipping on all orders over $ 500

Glofitamab

Cat. No. M25012

All AbMole products are for research use only, cannot be used for human consumption.

Glofitamab Structure
Synonym:

RO7082859

Size Price Availability Quantity
100ug USD 250  USD250 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Glofitamab (RO7082859) is a T-cell-engaging bispecific antibody possessing a novel 2:1 structure with bivalency for CD20 on B cells and monovalency for CD3 on T cells. Glofitamab leads to T-cell activation, proliferation, and tumor cell killing upon binding to CD20 on malignant cells. Glofitamab induces durable complete remissions in relapsed or refractory B-Cell lymphoma.

Chemical Information
CAS Number 2229047-91-8
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Michael J Dickinson, et al. N Engl J Med. Glofitamab for Relapsed or Refractory Diffuse Large B-Cell Lymphoma

[2] Vera Rentsch, et al. Cancers (Basel). Glofitamab Treatment in Relapsed or Refractory DLBCL after CAR T-Cell Therapy

[3] Ann-Marie E Bröske, et al. Blood Adv. Pharmacodynamics and molecular correlates of response to glofitamab in relapsed/refractory non-Hodgkin lymphoma

[4] Adrian Minson, et al. Leuk Lymphoma. Glofitamab CD20-TCB bispecific antibody

[5] Martin Hutchings, et al. J Clin Oncol. Glofitamab, a Novel, Bivalent CD20-Targeting T-Cell-Engaging Bispecific Antibody, Induces Durable Complete Remissions in Relapsed or Refractory B-Cell Lymphoma: A Phase I Trial

Related CD20 Products
Obinutuzumab

Obinutuzumab (GA101) is a fully humanized monoclonal antibody that binds to an epitope on CD20.

Ofatumumab

Ofatumumab is a humanised anti-CD20 monoclonal antibody, which appears to inhibit early-stage B lymphocyte activation.

Rituximab

Rituximab is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM, MW: 143.86 KD.

Ripertamab

Ripertamab (SCT400) is a recombinant, human-mouse chimeric anti-CD20 IgG1κ mAb. Ripertamab can be used for the research of hematological malignancies, including non-Hodgkin’s lymphoma (NHL).

Zuberitamab

Zuberitamab (HS006) is a monoclonal antibody that targets CD20 and can be used in cancer research, including diffuse large B-cell lymphoma.

  Catalog
Abmole Inhibitor Catalog




Keywords: Glofitamab, RO7082859 supplier, CD20, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.