All AbMole products are for research use only, cannot be used for human consumption.
Gartisertib (VX-803) is an ATP-competitive, orally active, selective ATR inhibitor with Ki<150 pM. Gartisertib inhibits atR-driven phosphorylation of checkpoint kinase-1 (Chk1) with an IC50 value of 8 nM. It has antitumor activity.
| Molecular Weight | 541.55 |
| Formula | C25H29F2N9O3 |
| CAS Number | 1613191-99-3 |
| Solubility (25°C) | DMSO ≥ 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related ATM/ATR Products |
|---|
| KU-55933
KU-55933 is a cell-permeable ATP-competitive inhibitor of ATM (IC50 = 13 nM; Ki = 2.2 nM) with selectivity over other PIKK family kinases (IC50 = 2.5, 9.3, 16.6 μM for DNAPK, mTOR, PI 3-K, respectively; IC50 > 100 μM for PI 4-K and ATR). |
| KU-60019
KU-60019 is a potent ATM kinase inhibitor with IC50 of 6.3 nM. |
| VE-821
VE-821 is a highly selective and potent ATR inhibitor with IC50 of 26 nM. |
| ETP-46464
ETP-46464 is a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα and ATM with IC50 of 0.6, 14, 36, 170 and 545 nM, respectively. |
| CP-466722
Cp-466722 is a reversible ATM inhibitor with IC50 value of 4.1 μM, but has no effect on PI3K, PIKK family proteins. |
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Products are for research use only. Not for human use. We do not sell to patients.
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