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Ganoderic acid D is a highly oxidized tetracyclic triterpenoid that is the main active ingredient in Ganoderma lucidum. Ganoderic acid D upregulates protein expression for SIRT3 and induces deacetylated cyclophilic protein D (CypD) through SIRT3. Ganoderic acid D inhibits energy reprogramming in colon cancer cells, including glucose uptake, lactate production, pyruvate, and acetyl-Coenzyme production in colon cancer cells.
| Molecular Weight | 514.65 |
| Formula | C30H42O7 |
| CAS Number | 108340-60-9 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Sirtuin Products |
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| Selisistat
Selisistat (EX 527) is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 98 nM. |
| SRT1720 Hydrochloride
SRT1720 Hydrochloride is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). SRT1720 increased the activity of SIRT1 and AMPKα phosphorylation at Ser485 via the cAMP-protein kinase A (PKA) pathway. |
| Resveratrol
Resveratrol is a phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects. |
| Balsalazide disodium
Balsalazide is an anti-inflammatory compound used to study inflammatory bowel disease and ulcerative colitis. |
| Sirtinol
Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM, respectively. |
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