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G6PDi-1 

Cat. No. M29658

All AbMole products are for research use only, cannot be used for human consumption.

G6PDi-1  Structure
Size Price Availability Quantity
1mg USD 60  USD60 In stock
5mg USD 120  USD120 In stock
10mg USD 200  USD200 In stock
25mg USD 390  USD390 In stock
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Biological Activity

G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50 of 0.07 μM. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells.

Chemical Information
Molecular Weight 284.34
Formula C14H12N4OS
CAS Number 2457232-14-1
Form Solid
Solubility (25°C) DMSO 50 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Patrick Watermann, et al. Neurochem Res. G6PDi-1 is a Potent Inhibitor of G6PDH and of Pentose Phosphate pathway-dependent Metabolic Processes in Cultured Primary Astrocytes

[2] Patrick Watermann, et al. Neurochem Res. β-lapachone-mediated WST1 Reduction as Indicator for the Cytosolic Redox Metabolism of Cultured Primary Astrocytes

[3] Jonathan M Ghergurovich, et al. Nat Chem Biol. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway

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Keywords: G6PDi-1  supplier, PDI, inhibitors, activators

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