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FX-11

Cat. No. M14457

All AbMole products are for research use only, cannot be used for human consumption.

FX-11 Structure
Synonym:

LDHA Inhibitor FX11

Size Price Availability Quantity
1mg USD 45  USD45 In stock
5mg USD 120  USD120 In stock
10mg USD 170  USD170 In stock
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Biological Activity

FX-11 (LDHA Inhibitor FX11) is a potent lactate dehydrogenase A (LDHA) inhibitor with an IC50 of 23.3 μM for HeLa cell and a Ki value of 8 μM. FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death.

FX-11 (0-100 µM, 72 h) impedes cell proliferation in BxPc-3 and MIA PaCa-2 cells. FX-11 (2.1 mg/kg; IP; administered daily for 10-14 days) suppresses P493 tumor growth.

Chemical Information
Molecular Weight 350.41
Formula C22H22O4
CAS Number 213971-34-7
Form Solid
Solubility (25°C) DMSO 150 mg/mL
Storage Powder -20°C
References

[1] Goran Hamid Mohammad, et al. Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer

[2] Bradley T Scroggins, et al. Hyperpolarized [1- 13 C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect

[3] Lu Jiang, et al. [Cr 3 O(O 2 CCH 2 CH 3) 6(H 2 O) 3]NO 3·H 2 O (Cr3) Toxicity Potential in Bacterial and Mammalian Cells

[4] Changkun Hu, et al. Synergism of Dam, MutH, and MutS in methylation-directed mismatch repair in Escherichia coli

[5] J M Johnson 3rd, et al. Identification of a mutation causing increased expression of the tas gene in Escherichia coli FX-11

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Keywords: FX-11, LDHA Inhibitor FX11 supplier, LDH, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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