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Fuzapladib

Cat. No. M45137

All AbMole products are for research use only, cannot be used for human consumption.

Fuzapladib Structure
Synonym:

IS-741

Size Price Availability Quantity
10mM*1mL in DMSO USD 360  USD360 In stock
5mg USD 270  USD270 In stock
10mg USD 390  USD390 In stock
25mg USD 860  USD860 In stock
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Quality Control & Documentation
Biological Activity

Fuzapladib is a leukocyte adhesion molecule and an orally active inhibitor of leukocyte function-associated antigen type 1 (LFA-1) activation.Fuzapladib is also a phospholipase A2 (PLA2) inhibitor, which exerts anti-inflammatory activity by inhibiting the migration of leukocytes to sites of inflammation.

Chemical Information
Molecular Weight 379.40
Formula C15H20F3N3O3S
CAS Number 141283-87-6
Form Solid
Solubility (25°C) DMSO 100 mg/mL
Storage 4°C, protect from light
References

[1] Joerg M Steiner, et al. J Vet Intern Med. Fuzapladib in a randomized controlled multicenter masked study in dogs with presumptive acute onset pancreatitis

[2] Noriyuki Kaji, et al. J Vet Med Sci. Fuzapladib reduces postsurgical inflammation in the intestinal muscularis externa

[3] Hideyuki Sato, et al. Pharm Dev Technol. Development of stabilized fuzapladib solution for injection: forced degradation study and pharmacokinetic evaluation

[4] Marnin A Forman, et al. J Vet Intern Med. ACVIM consensus statement on pancreatitis in cats

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Keywords: Fuzapladib, IS-741 supplier, Integrin, inhibitors, activators

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