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Etanercept is a dimer fusion protein that binds tumor necrosis factor (TNF) as a TNF inhibitor. Etanercept competitively inhibits the binding of TNF-α and TNF-β to TNF receptors on the cell surface, rendering tumor necrosis factor biologically inactive.
Immun Inflamm Dis. 2022 Dec;10(12):e734.
Etanercept alleviates psoriasis by reducing the Th17/Treg ratio and promoting M2 polarization of macrophages
Etanercept purchased from AbMole
Molecules. 2019 Oct 9;24(20).
M860, a Monoclonal Antibody against Human Lactoferrin, Enhances Tumoricidal Activity of Low Dosage Lactoferrin via Granzyme B Induction.
Etanercept purchased from AbMole
| Cell Experiment | |
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| Animal models | CIA rats |
| Formulation | |
| Dosages | 5 mg/kg |
| Administration | s.c. |
| Molecular Weight | 51234.33 |
| Formula | C2224H3475N621O698S36 |
| CAS Number | 185243-69-0 |
| Storage | -80°C for long term |
| Related Fusion Proteins Products |
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| Aflibercept
Aflibercept is a vascular epidermal growth factor (VEGF-A and PlGF) receptor inhibitor that inhibits the growth of neovascularization. It can be used to study a variety of diseases caused by ocular neovascularization. |
| Abatacept
Abatacept is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1. Abatacept binds to antigen presenting cells CD80 and CD86, blocks costimulatory signals and inhibits T cell activation, and is used in the study of rheumatoid arthritis and juvenile rheumatoid arthritis. |
| Batiraxcept
Batiraxcept (AVB-S6-500) is a highly potent and specific GAS6-AXL signaling pathway inhibitor, a recombinant fusion protein dimer containing the extracellular domain of human AXLM and human immunoglobulin G1 heavy chain (Fc). Batiraxcept binds to GAS6 and inhibits the interaction of GAS6 with AXL, thereby substantially reducing AXL signaled invasion and migration of highly metastatic cells in vitro. |
| Sotatercept
Sotatercept (ACE-011; MK-7962) is a first-in-class activin receptor 2A (ACVR2A) type IgG Fc fusion protein. Sotatercept combines activin and growth differentiation factor to try to restore the balance between growth promotion and growth inhibition signal pathways. Sotatercept has potential application in pulmonary arterial hypertension, anemia, bone loss, erythropoiesis, multiple myeloma (MM) osteolytic lesions. |
| Ramatercept
Ramatercept is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy. |
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Products are for research use only. Not for human use. We do not sell to patients.
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