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EPQpYEEIPIYL

Cat. No. M43968

All AbMole products are for research use only, cannot be used for human consumption.

EPQpYEEIPIYL Structure
Size Price Availability
1mg USD 350  USD350 1-2 Weeks
5mg USD 1080  USD1080 1-2 Weeks
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Quality Control & Documentation
Biological Activity

EPQpYEEIPIYL is a phosphopeptide and ligand for the Src homology 2 (SH2) structural domain that activates Src family members (e.g., Lck, Hck, Fyn) by binding to the SH2 domain.

Chemical Information
Molecular Weight 1473.52
Formula C66H97N12O24P
CAS Number 147612-86-0
Form Solid
Solubility (25°C) Water 2 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Nico J de Mol, et al. Bioorg Med Chem. Experimental and calculated shift in pK(a) upon binding of phosphotyrosine peptide to the SH2 domain of p56(lck)

[2] W Zhang, et al. Biochemistry. Self-association and backbone dynamics of the hck SH2 domain in the free and phosphopeptide-complexed forms

[3] M Tessari, et al. Biochemistry. Heteronuclear NMR studies of the combined Src homology domains 2 and 3 of pp60 c-Src: effects of phosphopeptide binding

[4] G Payne, et al. Chem Biol. The phosphopeptide-binding specificity of Src family SH2 domains

[5] M J Eck, et al. Nature. Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

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Keywords: EPQpYEEIPIYL supplier, Src-bcr-Abl, inhibitors, activators

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