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Eniporide hydrochloride (EMD-96785 hydrochloride) is a Na(+)/H(+) exchange (NHE) inhibitor that specifically inhibits the NHE-1 isoform. In addition, Eniporide improves cardiac performance depression associated with myocardial ischemia/reperfusion in animals, limits infarct size, and modulates cardiac performance and high-energy phosphate content in a clinically relevant porcine model of extracorporeal circulation (CPB) and cardiac arrest.
| Molecular Weight | 356.83 |
| CAS Number | 211813-86-4 |
| Solubility (25°C) | DMSO 55 mg/mL Water 4.17 mg/mL |
| Storage | 2-8°C, dry, sealed |
| Related Na+/H+ Exchanger (NHE) Products |
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| Tenapanor
Tenapanor is an inhibitor of the Na+/H+ exchanger NHE3 with IC50 values of 5 and 10 nM against human and Rat NHE3, respectively. |
| KR-32568
KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC50 value of 0.23 μM. |
| Cariporide
Cariporide is a selective inhibitor of the Na+/H+ exchanger subtype 1 (NHE-1), also known as the Na+/H+ antiporter. |
| EMD-87580
EMD-87580 is a selective inhibitor of the Na+/H+ exchanger subtype 1 (NHE-1), also known as the Na+/H+ antiporter. |
| FR183998 free base
FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively. |
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