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Endothelin-1 (human, porcine) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin-1 acts through two types of receptors ETA and ETB. ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion.
Sci Rep. 2025 Feb 15;15(1):5626.
Identification of ECE2 signaling in promoting non-small lung cancer progression through ET1/YAP1/MAGEA3 axis
Endothelin-1 (human, porcine) purchased from AbMole
Cytotherapy. 2024 Jul 24.
Human neural stem cells transplanted during the sequelae phase alleviate motor deficits in a rat model of cerebral palsy
Endothelin-1 (human, porcine) purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | Cardiomyocytes |
| Preparation method | Cardiomyocytes were cultured in 24-well culture plates. Twelve hours after the addition of rotenone (1 μM), endothelin-1 (10 nM) or vehicle was added to the medium. Concomitantly, 37 kBq of 2-deoxyglucose solution was added to the culture medium. The cells were incubated for 7 h. Then, the medium was aspirated, and the cells were washed twice with ice-cold phosphate-buffered saline. |
| Concentrations | 10 nM |
| Incubation time | 7 h |
| Animal Experiment | |
|---|---|
| Animal models | Male Swiss mice |
| Formulation | PBS |
| Dosages | 1 to 30 pmol/paw (20 μL) |
| Administration | i.pl. injection |
| Molecular Weight | 2491.9 |
| Formula | C109H159N25O32S5 |
| CAS Number | 117399-94-7 |
| Solubility (25°C) | Soluble in water |
| Storage | -20°C, dry, protect from light, sealed |
| Related Endothelin Receptor Products |
|---|
| Zibotentan
Zibotentan (ZD4054) is a more selective and specific endothelin-A receptor (ETAR) antagonist with an IC50 value of 21 nM. |
| Ambrisentan
Ambrisentan is an orally active, highly selective antagonist of the endothelin-1 type A receptor. |
| Sitaxsentan sodium
Sitaxsentan (TBC-11251) is an orally active, highly selective antagonist of endothelin A receptors. |
| Macitentan
Macitentan is an orally-active, tissue-targeting dual ET receptor antagonist. |
| Bosentan Hydrate
Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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