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Elenbecestat (E2609) is a highly potent, orally active BACE-1 inhibitor that transmits CNS. Elenbecestat has the potential to be used in the study of Alzheimer's disease (AD).
| Molecular Weight | 437.44 |
| Formula | C19H18F3N5O2S |
| CAS Number | 1388651-30-6 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related BACE Products |
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| LY2886721
LY2886721 is an effective, selective, orally active inhibitor of beta-site amyloid precursor protein lyase 1 (BACE1) with an IC50 of 20.3 nM against recombinant human BACE1. LY2886721 showed higher selectivity for BACE1 than cathepsin D, pepsin and renin, but lacked selectivity for BACE2 (IC50 was 10.2 nM). LY2886721 crosses the blood-brain barrier and can be used to study Alzheimer's disease. |
| AZD3839
AZD3839 is a potent and selective inhibitor of human BACE1 with Ki of 26.1 nM. |
| Lanabecestat
Lanabecestat (AZD3293, LY3314814) is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor. |
| Eslicarbazepine Acetate
Eslicarbazepine acetate is an antiepileptic drug. |
| Verubecestat (MK-8931)
Verubecestat (MK-8931) is an orally active, high-affinity (beta-secretase 1) BACE1 and BACE2 inhibitor, with Ki values of 2.2 nM and 0.38 nM, respectively. |
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