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EB1 is the inhibitor of kinases MNK with IC50s of 0.69 μM (MNK1) and 9.4 μM (MNK2). EB1 selectively inhibits the growth of cancer cells, but not normal cells. EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation.
| Molecular Weight | 286.33 |
| Formula | C18H14N4 |
| CAS Number | 42951-68-8 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[1] Xiaoyu Song, et al. Nat Cell Biol. Phase separation of EB1 guides microtubule plus-end dynamics
[3] Maria Angeles Juanes, et al. Curr Biol. EB1 Directly Regulates APC-Mediated Actin Nucleation
[5] Ewan E Morrison. Adv Exp Med Biol. The APC-EB1 interaction
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| Tomivosertib (eFT-508)
Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. |
| SLV-2436
SLV-2436 (SEL201-88) is a novel ATP-competitive inhibitor of MNK1 and MNK2 with IC50 of 10.8 nM and 5.4 nM, respectively. |
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