Free shipping on all orders over $ 500

DODAP

Cat. No. M25509

All AbMole products are for research use only, cannot be used for human consumption.

DODAP Structure
Synonym:

1,2-Dioleoyl-3-dimethylammonium-propane

Size Price Availability Quantity
5mg USD 48  USD48 In stock
10mg USD 70  USD70 In stock
50mg USD 170  USD170 In stock
100mg USD 210  USD210 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

DODAP is a cationic lipid. The ionizable lipid DODAP is a lipid component of the liposome. DODAP can be used to encapsulate siRNA, immunostimulatory chemotherapeutic agents for in vitro and in vivo delivery and so on.

1,2-Dioleoyl-3-dimethylammonium-propane (DODAP) is an ionizable cationic lipid (pKa = 5.59 in a TNS binding assay). It has been used as a component in liposomes that can be used to encapsulate siRNA, immunostimulatory oligodeoxynucleotides, antisense oligonucleotides, or chemotherapeutic agents for in vitro and in vivo delivery.

Chemical Information
Molecular Weight 648.05
Formula C41H77NO4
CAS Number 127512-29-2
Form Oily Liquid
Solubility (25°C) DMSO 90 mg/mL
Storage -20°C, protect from light, sealed
References

[1] Azizah Algarni, et al. Biomater Sci. In vivo delivery of plasmid DNA by lipid nanoparticles: the influence of ionizable cationic lipids on organ-selective gene expression

[2] Makhloufi Zoulikha, et al. Acta Pharm Sin B. Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome

[3] Manuel J Carrasco, et al. Commun Biol. Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration

[4] Mark Gontsarik, et al. J Colloid Interface Sci. pH-responsive aminolipid nanocarriers for antimicrobial peptide delivery

[5] Seigo Kimura, et al. J Control Release. Novel lipid combination for delivery of plasmid DNA to immune cells in the spleen

[6] P Mitrakos, et al. Biochemistry. Domains in cationic lipid plus polyelectrolyte bilayer membranes: detection and characterization via 2H nuclear magnetic resonance

Related Cell Transfection Products
Chitosan (MW 100000)

Chitosan is a natural polycationic linear polysaccharide derived from chitin.

Hexadimethrine bromide

Hexadimethrine bromide can be used to transfect mammalian cells with DNA. It can be used to increase the efficiency of lipofection transfections.In addition, Polybrene can be used as a promoter in virus-mediated gene therapy assays and in studies of gene transfer.

DOTAP chloride

DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids.

DSPE-PEG-2K-Amine

DSPE-PEG-2K-Amine is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE, used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.

DOPE

DOPE (1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine) forms heterogenous liposomes with N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfate (DOTAP), which are used as delivery vehicles for therapeutic agents.

  Catalog
Abmole Inhibitor Catalog




Keywords: DODAP, 1,2-Dioleoyl-3-dimethylammonium-propane supplier, Cell Transfection, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.