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DMOG (Dimethyloxaloyl glycine) is an antagonist of α-ketoglutarate cofactor and a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1α stabilisation and accmulation in vitro and in vivo. DMOG is an α-ketoglutarate analogue and inhibits α-KG-dependent hydroxylases. DMOG induces cell autophagy.
DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal. DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice.
Redox Biol. 2025 Jul 08; .
Hypoxia, cuproptosis, and osteoarthritis: Unraveling the molecular crosstalk
DMOG purchased from AbMole
Nanomaterials (Basel). 2022 Jan 3;12(1):163.
Liposomal PHD2 Inhibitors and the Enhanced Efficacy in Stabilizing HIF-1α
DMOG purchased from AbMole
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Source | Int J Biol Sci (2018). Figure 3. DMOG |
| Method | Western blot | |
| Cell Lines | BMSCs | |
| Concentrations | 0.5mM | |
| Incubation Time | 48 h | |
| Results | The number of surviving BMSCs cultured in normoxic condition was 8.3×10^3. The number of surviving cells number was 3.9×10^4 in the DMOG-treated group. |
| Molecular Weight | 175.14 |
| Formula | C6H9NO5 |
| CAS Number | 89464-63-1 |
| Solubility (25°C) | DMSO ≥ 70 mg/mL Water 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Jessica M Falcon, et al. DMOG Negatively Impacts Tissue Engineered Cartilage Development
| Related HIF Products |
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| FG-4592 (Roxadustat)
FG-4592 (Roxadustat; ASP1517) is a novel Hypoxia Inducible Factor Prolyl Hydroxylase inhibitor. |
| 2-Methoxyestradiol
2-methoxyestradiol (2-ME2), an endogenous metabolite of 17β -estradiol (E2) with oral activity, is an apoptosis inducer and angiogenesis inhibitor with effective antitumor activity. Methoxyestradiol can also destabilize microtubules. Methoxyestradiol is a potent inhibitor of superoxide dismutase (SOD) and reactive oxygen species (ROS) that can induce autophagy in transformed cell line HEK293, cancer cell line U87 and HeLa. |
| IOX2
IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH. |
| Hydralazine hydrochloride
Hydralazine hydrochloride is a hydrochloride salt of hydralazine (Apresoline) that is a direct-acting smooth muscle relaxant with an IC50 of 1.9 mM. |
| Paeoniflorin
Paeoniflorin is a glycoside isolated from the root of Paeonia lactiflora. Paeoniflorin has been used as an anticonvulsant and has hypoglycemic effect. |
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