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DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery.
| Molecular Weight | 616.06 |
| CAS Number | 871258-12-7 |
| Form | Liquid |
| Solubility (25°C) | Ethanol ≥ 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Sean C Semple, et al. Rational design of cationic lipids for siRNA delivery
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Replacing cholesterol in lipid nanoparticle (LNP) formulations with β-Sitosterol, a natural phytosterol, significantly improves mRNA delivery. |
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| DLin-MC3-DMA
DLin-MC3-DMA is the most potent cationic lipid that has been synthesized for lipid nanoparticles (LNPs) to deliver the siRNA. |
| Sunflower phospholipids
Sunflower phospholipids can be used for the preparation of liposomes. It has been shown to play important roles in many important areas, including maintenance of cellular structure, fat metabolism, memory, nerve signaling, acting as a precursor of important neurotransmitters, and liver health. |
| DLin-KC2-DMA
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6), produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). |
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