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CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase inhibitor, with IC50s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively. CVT-12012 demonstrates good oral bioavailability (78%) in a rat PK study.
| Molecular Weight | 434.41 |
| Formula | C21H21F3N4O3 |
| CAS Number | 1018675-35-8 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Stearoyl-CoA Desaturase Products |
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| MK-8245
MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. |
| Aramchol
Aramchol is a novel fatty acid bile acid coupling agent with oral activity and an inhibitor of SCD1, which acts by inhibiting SCD1 expression in hepatocytes and hepatic astrocytes, and can be used in studies related to non-alcoholic steatohepatitis (NASH). |
| CAY10566
CAY10566 is a potent and selective inhibitor of SCD1 that demonstrates IC50 values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. CAY10566 blocks the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM) |
| GSK1940029
GSK1940029 (SCD inhibitor 1) is a potent acyl-CoA desaturase (SCD) inhibitor. |
| A939572
A939572 is a potent, orally active stearyl CoA desaturase 1 SCD1 inhibitor that acts on mSCD1 and hSCD1 with IC50 <4 nM and 37 nM, respectively. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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