All AbMole products are for research use only, cannot be used for human consumption.
Concanamycin A (Folimycin) is a macrolide antibiotic and a specific vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A inhibits acidification of organelles and perforin-mediated cytotoxicity. In the CD8(+) CTL clone, Concanamycin A (CMA) induced a marked DNA fragmentation and nuclear condensation characteristic of apoptosis.
Int J Mol Sci. 2021 Aug 16;22(16):8779.
Autophagy Mediates the Degradation of Plant ESCRT Component FREE1 in Response to Iron Deficiency
Concanamycin A (Folimycin) purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | The wild-type strain BY4741 |
| Preparation method | Cells were treated with 0, 1, 2, 3, 5, 10, and 20 μM concanamycin A in the presence of 0.5% DMSO and were incubated for 30 min at 30 °C with rocking. |
| Concentrations | 0, 1, 2, 3, 5, 10, and 20 μM |
| Incubation time | 30 min |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 866.09 |
| Formula | C46H75NO14 |
| CAS Number | 80890-47-7 |
| Solubility (25°C) | Limited soluble in DMSO |
| Storage | 2-8°C, dry, sealed |
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|---|
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Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells. Brefeldin A is also an autophagy and mitophagy inhibitor. Brefeldin A is a CRISPR/Cas9 activator. Brefeldin A inhibits HSV-1 and has anti-cancer activity. |
| BTB06584
BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase. |
| Golgicide A
Golgicide A is a potent and rapidly reversible GBF1 inhibitor. |
| Rostafuroxin
Rostafuroxin, a novel antihypertensive compound, acts as a selective inhibitor of srC-SH2 interaction with Na, K-ATPase activated by mutated adducin and Wabin in vivo. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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