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Cl-amidine 

Cat. No. M30880

All AbMole products are for research use only, cannot be used for human consumption.

Cl-amidine  Structure

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Quality Control & Documentation
Biological Activity

Cl-amidine is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine induces apoptosis in cancer cells. Cl-amidine induces microRNA (miR)-16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model.

Chemical Information
Molecular Weight 310.78
Formula C14H19ClN4O2
CAS Number 913723-61-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Ming Zhai, et al. Nat Commun. Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis

[2] Jianxin Du, et al. Hum Cell. Cl-amidine attenuates lipopolysaccharide-induced inflammation in human gingival fibroblasts via the JNK/MAPK, NF-κB, and Nrf2 signalling pathways

[3] Dina Ahmed, et al. Int J Mol Sci. Controlled Delivery of Pan-PAD-Inhibitor Cl-Amidine Using Poly(3-Hydroxybutyrate) Microspheres

[4] Chaoqun Wang, et al. Microb Pathog. Cl-amidine attenuates lipopolysaccharide-induced mouse mastitis by inhibiting NF-κB, MAPK, NLRP3 signaling pathway and neutrophils extracellular traps release

[5] Ali Z Siddiqui, et al. Surg Infect (Larchmt). Cl-Amidine Improves Survival and Attenuates Kidney Injury in a Rabbit Model of Endotoxic Shock

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  Catalog
Abmole Inhibitor Catalog




Keywords: Cl-amidine  supplier, PAD, inhibitors, activators

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