All AbMole products are for research use only, cannot be used for human consumption.
Capsazepine is a specific vanilloid receptor antagonist; synthetic analog of capsaicin.
J Periodontal Res. 2024 Dec 01.
TRPV1 Promotes Periodontitis Tissue Inflammation and Oxidative Damage by Regulating STAT3 Signaling Pathway
Capsazepine purchased from AbMole
Iran J Basic Med Sci. 2022 May;25(5):635-642.
Transient receptor potential vanilloid type-1 regulates periodontal disease damage via the PI3K/AKT signaling pathway
Capsazepine purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | Prostate cancer cells |
| Preparation method | The culture medium was replaced with 100 μl of serum-free medium containing 0–200 μM capsazepine. The cell proliferation reagent WST-1 (4-[3-[4-lodophenyl]-2-4(4-nitrophenyl)-2H-5-tetrazolio-1,3-benzene disulfonate] (10 μl pure solution) was added to each sample 16 h after capsazepine treatment, and cells were incubated for additional 30 min in a humidified 37 °C atmosphere. |
| Concentrations | 0–200 μM |
| Incubation time | 16 h |
| Animal Experiment | |
|---|---|
| Animal models | Osteosarcoma-bearing mice |
| Formulation | Capsazepine was dissolved in DMSO (15%) |
| Dosages | 3–10 mg/kg |
| Administration | The effects induced by the s.c. administration of Capsazepine (3–10 mg/kg) |
| Molecular Weight | 376.9 |
| Formula | C19H21ClN2O2S |
| CAS Number | 138977-28-3 |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Darine Fakih, et al. Capsazepine decreases corneal pain syndrome in severe dry eye disease
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