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BVT-14225

Cat. No. M14664

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BVT-14225 Structure

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Quality Control & Documentation
Biological Activity

BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 52 nM.

Chemical Information
Molecular Weight 401.93
CAS Number 376638-65-2
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Gabriel Navarrete-Vzquez, et al. Synthesis of 2-{2-[(α/β-naphthalen-1-ylsulfonyl)amino]-1,3-thiazol-4-yl} acetamides with 11β-hydroxysteroid dehydrogenase inhibition and in combo antidiabetic activities

[2] Hye Hyun Yoo, et al. Enantioselective carbonyl reduction of eperisone in human liver microsomes

[3] Nigel Vicker, et al. Novel non-steroidal inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1

Related Hydroxysteroid dehydrogenase Products
Carbenoxolone Sodium

Carbenoxolone, a synthetic derivative of glycyrrhetinic acid, is also used as a blocker of the enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD), of pannexon membrane channels (comprising 6 subunits of pannexin) and the related innexon channels.

ASP9521

ASP9521 is a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3).

  Catalog
Abmole Inhibitor Catalog




Keywords: BVT-14225 supplier, Hydroxysteroid dehydrogenase, inhibitors, activators

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