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BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM. BRD3308 is 23 times more selective to HDAC3 than HDAC1 (IC50:1.26 μM) or HDAC2 (IC50:1.34 μM). BRD3308 inhibits pancreatic β cell apoptosis induced by inflammatory cytokines or glucolipid toxic stress and increases functional insulin release. BRD3308 also activates HIV-1 transcription and disrupts HIV-1 latency.
| Molecular Weight | 287.29 |
| Formula | C15H14FN3O2 |
| CAS Number | 1550053-02-5 |
| Form | Solid |
| Solubility (25°C) | DMSO: 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Kirston M Barton, et al. Selective HDAC inhibition for the disruption of latent HIV-1 infection
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Products are for research use only. Not for human use. We do not sell to patients.
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