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AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively.
| Molecular Weight | 478.87 |
| Formula | C19H18ClF3N2O5S |
| CAS Number | 252017-04-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] J A Morrell, et al. AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2
| Related PDK1 Products |
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OSU-03012 is a novel and potent, blood-brain permeable inhibitor of PDK-1 with an IC50 of 5 µM. |
| GSK2334470
GSK2334470 is a highly specific and potent inhibitor of PDK1 with IC50 of 10 nM. |
| BX-795
BX795 is a potent and specific TBK1, IKKε and PDK-1 inhibitor with IC50 of 6 nM, 41 nM and 111 nM, respectively. |
| BX-912
BX912 is a selective potent PDK1 inhibitor with IC50 of 12 nM. |
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NVP-BAG956 is a potent, ATP-competitive and selective dual PDK1 and class I PI 3-K inhibitor (IC50 values are 245, 56, 446, 35 and 117 nM for PDK1 and PI 3-K p110 -α, -β, -δ, and -γ respectively). |
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