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AZD 4017

Cat. No. M27656

All AbMole products are for research use only, cannot be used for human consumption.

AZD 4017 Structure

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For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.

Quality Control & Documentation

Purity: ≥99.0%
COA
MSDS

Product Information

Biological Activity

AZD 4017 is a potent, selective 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) inhibitor, with an IC50 of 7 nM.

Chemical Information

Molecular Weight	419.58
Formula	C22H33N3O3S
CAS Number	1024033-43-9
Form	Solid
Solubility (25°C)	DMSO 125 mg/mL (ultrasonic)
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

References

[1] Nantia Othonos, et al. Nat Commun. 11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial

[2] Afroze Abbas, et al. J Clin Endocrinol Metab. Effect of AZD4017, a Selective 11β-HSD1 Inhibitor, on Bone Turnover Markers in Postmenopausal Osteopenia

[3] R A Ajjan, et al. Eur J Endocrinol. Oral 11β-HSD1 inhibitor AZD4017 improves wound healing and skin integrity in adults with type 2 diabetes mellitus: a pilot randomized controlled trial

[4] Rowan S Hardy, et al. J Clin Endocrinol Metab. 11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension

Related Hydroxysteroid dehydrogenase Products
Carbenoxolone Sodium Carbenoxolone, a synthetic derivative of glycyrrhetinic acid, is also used as a blocker of the enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD), of pannexon membrane channels (comprising 6 subunits of pannexin) and the related innexon channels.
ASP9521 ASP9521 is a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3).

Catalog

Abmole Inhibitor Catalog

Keywords: AZD 4017 supplier, Hydroxysteroid dehydrogenase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.

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