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Atrasentan hydrochloride (ABT-627 hydrochloride) is a potent, orally active, selective endothelin A (ETA) receptor antagonist that inhibits ETA activity and blocks endothelin-induced cellular proliferation with an IC50 value of 0.0551 nM. It can be used in studies related to prostate cancer as well as IgA nephropathy (IgAN). It can be used in prostate cancer and IgA nephropathy (IgAN) related studies.
| Molecular Weight | 547.08 |
| Formula | C29H38N2O6 · HCl |
| CAS Number | 195733-43-8 |
| Solubility (25°C) | DMSO: 2 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Jesus Egido, et al. Atrasentan for the treatment of diabetic nephropathy
[3] A Kalliokoski, et al. Impact of OATP transporters on pharmacokinetics
| Related Endothelin Receptor Products |
|---|
| Zibotentan
Zibotentan (ZD4054) is a more selective and specific endothelin-A receptor (ETAR) antagonist with an IC50 value of 21 nM. |
| Ambrisentan
Ambrisentan is an orally active, highly selective antagonist of the endothelin-1 type A receptor. |
| Sitaxsentan sodium
Sitaxsentan (TBC-11251) is an orally active, highly selective antagonist of endothelin A receptors. |
| Macitentan
Macitentan is an orally-active, tissue-targeting dual ET receptor antagonist. |
| Bosentan Hydrate
Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. |
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