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APX-115 is a potent, orally active inhibitor of pan NADPH oxidase (Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 (5 μM; 60 min) almost completely suppresses high glucose-induced proinflammatory and profibrotic molecule expression in the mouse podocyte cell line.
APX-115 (oral gavage; 60 mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice.
| Molecular Weight | 279.34 |
| Formula | C17H17N3O |
| CAS Number | 1270084-92-8 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related NADPH Oxidase Products |
|---|
| GKT137831 (Setanaxib)
GKT137831 (Setanaxib) is a novel and specific dual Nox1/Nox4 inhibitor with Ki of 140±40 nM and 110±30 nM. |
| Apocynin
Apocynin is a nADPH-oxidase inhibitor. |
| ML171
ML171 is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively. ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC50 of 0.25 μM in HEK293-Nox1 confirmatory assay. |
| VAS2870
VAS2870 is a cell-permeable and specific NADPH oxidase (NOX) inhibitor that effectively suppresses growth factor-mediated ROS liberation in VSMC. |
| GLX351322
GLX351322 is an NADPH oxidase 4 inhibitor, which inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 uM. |
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