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AP1867 is a synthetic FKBP12F36V-directed ligand.
| Molecular Weight | 693.78 |
| Formula | C38H47NO11 |
| CAS Number | 195514-23-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] K Koide, et al. J Am Chem Soc. A synthetic library of cell-permeable molecules
| Related FKBP (FK506-binding protein) Products |
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Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD) |
| SAFit2
SAfit2 is a potent inhibitor of FK506-binding protein 51 (FKBP51) with a Ki value of 6 nM. SAfit2 has been used as a potential agent in the study of major depression, obesity, and chronic pain. |
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