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Acetylcysteine (NAC)

Cat. No. M5385

All AbMole products are for research use only, cannot be used for human consumption.

Acetylcysteine (NAC) Structure
Synonym:

N-Acetyl-L-cysteine; NAC; N-acetylcysteine; N-Acetyl-Cysteine

Size Price Availability Quantity
Free Sample (1-2 mg)  USD 0 In stock
500mg USD 30  USD30 In stock
1g USD 40  USD40 In stock
5g USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

Acetylcysteine (NAC; N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor.

Product Citations
Customer Product Validations & Biological Datas
Source Pathogens 2020 Aug. Figure 5. N-acetyl-l-cysteine (Abmole Bioscience Inc, Houston, TX, USA)
Method Cell Viability Assay
Cell Lines Caco-2 cells
Concentrations 10 mM/well
Incubation Time 6 h
Results It was shown in Figure 5A that pre-incubation of Caco-2 cells with NAC for 3 h before exposure to trophozoites could block the release of Cyt-c. The activation of CASP3 was diminished by NAC in trophozoites-treated cells
Protocol (for reference only)
Cell Experiment
Cell lines RAW264.7 cells
Preparation method RAW264.7 cells were stimulated with 1st LPS for 12 h followed by incubation with 2.5 mM NAC for 1 h before 0.04 mM metformin and 2nd LPS stimulation. In parallel experiments, RAW264.7 cells were pretreated with 100 μM TBHP for 20 min before 2nd LPS stimulation. The production of O TNF-α and P IL-6 was then determined via ELISA assays.
Concentrations 2.5 mM
Incubation time 1 h
Animal Experiment
Animal models Female Kunming mice
Formulation ddH2O
Dosages Mice was fed with water supplemented with 0.1 mM NAC
Administration Oral
Chemical Information
Molecular Weight 163.19
Formula C5H9NO3S
CAS Number 616-91-1
Solubility (25°C) DMSO 30 mg/mL
Water 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Qiuting Zhang, et al. J Cancer. Artemisinin Derivatives Inhibit Non-small Cell Lung Cancer Cells Through Induction of ROS-dependent Apoptosis/Ferroptosis

[2] Stutzman D, et al. Am J Health Syst Pharm. Acetylcysteine for treatment of autism spectrum disorder symptoms.

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Keywords: Acetylcysteine (NAC), N-Acetyl-L-cysteine; NAC; N-acetylcysteine; N-Acetyl-Cysteine supplier, ROS, inhibitors, activators

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