All AbMole products are for research use only, cannot be used for human consumption.
Abelacimab (MAA868) is a fully human IgG1 monoclonal antibody that binds with high affinity to the catalytic structural domain of FXI and locks it in the zymogen conformation, thereby preventing its activation by FXIIa or thrombin. Abelacimab can be used in thromboembolic disease studies.
| CAS Number | 2098724-83-3 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[1] Benjamin D Gallagher. N Engl J Med. Abelacimab for Prevention of Venous Thromboembolism
[2] Sudhamshi Toom, et al. N Engl J Med. Abelacimab for Prevention of Venous Thromboembolism
[3] Xiang Wang. N Engl J Med. Abelacimab for Prevention of Venous Thromboembolism
[5] Peter Verhamme, et al. N Engl J Med. Abelacimab for Prevention of Venous Thromboembolism
| Related Factor Xa Products |
|---|
| Apixaban
Apixaban is a highly selective, reversible and orally active direct factor Xa inhibitor with an IC50 of 0.22±0.02 µM. |
| Rivaroxaban
Rivaroxaban (Xarelto, BAY 59-7939) is oral direct factor Xa inhibitor with an IC50 value of 2.1nM. |
| Betrixaban
Betrixaban is a highly potent, selective, and orally efficacious factor Xa inhibitor with IC50 of 1.2 nM(inhibition of Factor 10a). |
| Edoxaban Tosylate Monohydrate
Edoxaban tosylate monohydrate is a selective factor Xa inhibitor with Ki of 0.561 nM, >10000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant compound. |
| BMS-740808
BMS-740808 is a highly potent, selective inhibitor of blood coagulation factor Xa (fXa) with Ki with 0.03 nM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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