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740 Y-P is a potent and cell permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone.
Cell Biol Toxicol. 2022 Apr;38(2):291-310.
Lnc-HZ08 regulates BPDE-induced trophoblast cell dysfunctions by promoting PI3K ubiquitin degradation and is associated with miscarriage
740 Y-P purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | U251 cells |
| Preparation method | For the treatment of 740 Y-P, culture medium containing 10 μM 740 Y-P was prepared. Then the stably infected U251 cells were incubated with 740 Y-P, followed by PI3K, AKT and p-AKT expression detection, cell proliferation and apoptosis assessment, drug chemosensitivity evaluation, sphere formation assay and ELDA detection, and CD44+CD133+ cell evaluation using the methods described above. |
| Concentrations | 10 μM |
| Incubation time | 24, 48, 72 h |
| Animal Experiment | |
|---|---|
| Animal models | MRL/Mp-lpr/lpr (MRL/lpr) mice |
| Formulation | DMSO |
| Dosages | 1.5 mg/kg/day |
| Administration | Intraperitoneally injected |
| Molecular Weight | 3270.70 |
| Formula | C141H222N43O39PS3 |
| CAS Number | 1236188-16-1 |
| Solubility (25°C) | DMSO 25 mg/mL Water ≥ 1 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
| Related PI3K Products |
|---|
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| BKM120 (Buparlisib)
BKM120 (NVP-BKM120) is a potent and highly specific oral pan-class I PI3K inhibitor. |
| GDC-0941 (Pictilisib)
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| AS-252424
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