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3-Aminobenzamide (PARP-IN-1) is a novel poly(ADP-ribose) polymerase (PARP) inhibitor, and it inhibits cell apoptosis after SCI (Spinal Cord Injury) in caspase-independent way.
Cell Death Dis. 2024 Jul 31;10(1):345.
Parthanatos initiated by ROS-induced DNA damage is involved in intestinal epithelial injury during necrotizing enterocolitis
3-Aminobenzamide purchased from AbMole
Bioact Mater. 2022 Feb 9.
pH and lipase-responsive nanocarrier-mediated dual drug delivery system to treat periodontitis in diabetic rats
3-Aminobenzamide purchased from AbMole
Cell Commun Signal. 2020 Feb 17;18(1):27.
mTOR May Interact With PARP-1 to Regulate Visible Light-Induced Parthanatos in Photoreceptors
3-Aminobenzamide purchased from AbMole
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Source | Exp Gerontol (2007). Figure 2. INO-1001 |
| Method | i.p. | |
| Cell Lines | male Lewis rats | |
| Concentrations | 5 mg/kg | |
| Incubation Time | 2 h | |
| Results | Single dose treatment with the potent PARP-inhibitor INO-1001 notably decreased PAR formation both in the myocardium and the aortic wall. |
| Cell Experiment | |
|---|---|
| Cell lines | cultured podocytes |
| Preparation method | Apoptosis detection. Apoptotic nuclei of cultured podocytes were detected on paraformaldehyde-fixed cells using DAPI (4′,6-diamidino-2-phenylindole) staining (1 μg/ml) for 10 min. Cells were analyzed under a fluorescence microscope and assessed for chromatin condensation and segregation. Caspase-3 activity was measured in podocyte extracts using EnzCheck Caspase-3 Assay kit (Molecular Probes) following the manufacturer’s protocol. Nuclear extracts were prepared using Transfactor DB Nuclear extraction kit (Clontech BD Bioscience) following the manufacturer’s protocol. Western blotting was performed using NFκB p50 (Santa Cruz Biotechnology) antibody. NFκB p50 nuclear binding assay was performed using TransFactor Colorimetric kit (Clontech BD) according to the manufacturer’s protocol. |
| Concentrations | 200 nmol/l |
| Incubation time | 45 min |
| Animal Experiment | |
|---|---|
| Animal models | diabetic nephropathy of Leprdb/db mice model |
| Formulation | sterile water |
| Dosages | 60 mg/kg initiated at 5 weeks of age to around 8 weeks of age |
| Administration | oral in drinking water |
| Molecular Weight | 136.15 |
| Formula | C7H8N2O |
| CAS Number | 3544-24-9 |
| Solubility (25°C) | DMSO 22 mg/mL Water ≥ 4 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PARP Products |
|---|
| ABT-888
ABT-888 (Veliparib) is a potent inhibitor of PARP-1 and PARP-2 with Ki values of 5.2nM and 2.9nM respectively. |
| AG-014699 phosphate
AG-014699 (PF-01367338, Rucaparib) is a PARP inhibitor with a Ki of 1.4 nM. |
| AG14361
AG14361 is a novel poly (ADP-ribose) polymerase-1 inhibitor with a GI50 of 10.9 µM. |
| AZD2281 (Olaparib)
AZD 2281 (Olaparib, KU-0059436) is a potent PARP (poly ADP-ribose polymerase) inhibitorwith IC50 of 5 and 1 nM for PARP-1and PARP-2 respectively. Olaparib is an autophagy and mitophagy activator. |
| Talazoparib
Talazoparib (BMN-673) is a highly potent, orally active PARP1/2 inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with Kis of 1.2 nM and 0.87 nM, respectively. Talazoparib has antitumor activity. |
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