| Cat.No. | Name | Information |
|---|---|---|
| M42066 | Polyinosinic acid | Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) agonist. |
| M11408 | Hydroxychloroquine | Hydroxychloroquine is a synthetic antimalarial agent that also inhibits Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine effectively inhibited SARS-COV-2 infection. |
| M9063 | TLR2-IN-C29 | C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocked HTLR2/1 and HTLR2/6 with IC50 values of 19.7 and 37.6 μM, respectively. |
| M5062 | Polyinosinic:polycytidylic acid | Polyinosinic:polycytidylic acid (poly I:C) is a synthetic polyinosinic-polycytidylic acid double-stranded RNA. Polyinosinic-polycytidylic acid (Poly (I:C)) is an agonist of toll-like receptor (TLR)-3. Polyinosinic-polycytidylic acid has protective effects against cerebral ischemia/reperfusion (I/R) injury and can be used as vaccine adjuvant to enhance innate and adaptive immune responses. |
| M4838 | TAK-242 (Resatorvid) | Resatorvid (TAK-242) is a selective TLR4 signaling inhibitor. Resatorvid inhibited the production of NO, TNF-α and IL-6 with IC50 values of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid down-regulates the expression of MyD88 and TRIF signaling molecules downstream of TLR4. Resatorvid inhibits autophagy and plays a key role in a variety of inflammatory diseases. |
| M2728 | Vesatolimod (GS-9620) | Vesatolimod (GS-9620) is an effective, selective, oral toll-like receptor 7 (TLR7) agonist with an EC50 value of 291 nM. |
| M59295 | RKH acetate | RKH acetate is a novel tripeptide Arg-Lys-His. RKH acetate can directly bind to Toll-like receptor 4 (TLR4) and block TLR4 signal transduction in immune cells. RKH acetate exerts protective effects against sepsis-induced death and organ damage. RKH may act as a novel endogenous antagonist for TLR4. |
| M58989 | 5-Iodoisoquinoline | 5-Iodoisoquinoline is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. 5-Iodoisoquinoline is selective against other NAD+-processing enzymes, receptors, and transporters. |
| M58317 | Pepinh-TRIF TFA | Pepinh-TRIF TFA blocks TIR-domain-containing adapter-inducing interferon-β (TRIF) signaling by interfering with TLR-TRIF interaction. |
| M58146 | TLR4-IN-C34-C2-COOH | TLR4-IN-C34-C2-COO is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. |
| M52830 | Pam2CSK4 | Pam2CSK4, a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. |
| M31226 | Chitohexaose hexahydrochloride | Chitohexaose hexahydrochloride is a chitosan oligosaccharide with anti-inflammatory effect. Chitohexaose hexahydrochloride binds to the active sites of TLR4 and inhibits LPS induced inflammation. |
| M29890 | MMG-11 | MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7 µM for Pam3CSK4-induced hTLR2/1 and 5.7 µM for Pam2CSK4-induced hTLR2/6 responses. |
| M28034 | Monophosphoryl lipid A | Monophosphoryl lipid A (Glucopyranosyl lipid A) is a toll-like receptor 4 agonist. Monophosphoryl lipid A is derived from the cell wall of nonpathogenic Salmonella. Monophosphoryl lipid A can be used for the research of immunization and vaccine. |
| M22406 | Beta-(1,3)-D-Glucan | D-Glucan (Beta-Glucan) is an orally effective Dectin-1 receptor immune activator with antioxidant properties (reducing TNF-α). D-Glucan activates macrophages and neutrophils to scavenge free radicals, inhibit oxidative stress and inflammatory responses, and improve insulin sensitivity. D-Glucan promotes glycolysis by enhancing the activity of the antioxidant enzyme glutathione, inhibiting gluconeogenesis and activating GK. |
| M21562 | Zymosan A (from Saccharomyces cerevisiae) | Zymosan A can increase the level of cyclin D2, suggesting the role of cyclin D2 in macrophage activation and proliferation. After injection of galactosamine, it aggravated acute liver injury, suggesting that some non-parenchymal cells besides Kupfer's cells were involved in fermentase action. |
| M21418 | CL097 | CL097 is a potent TLR7 and TLR8 agonist that induces pro-inflammatory cytokines in macrophages.CL097 induces NADPH oxidase initiating activity leading to increased fMLF-stimulated ROS production. |
| M20588 | MD2-IN-1 | MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD value of 189 μM. |
| M19443 | Robinin | Robinin inhibits upregulated expression of TLR2 and TLR4. Robinin ameliorates oxidized low density lipoprotein (Ox-LDL) induced inflammatory insult through TLR4/NF-κB pathway. |
| M16160 | Stepharine | Stepharine is an natural alkaloid which directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects. |
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