| Cat.No. | Name | Information |
|---|---|---|
| M45323 | Blarcamesine | Blarcamesine is a Sigma-1 receptor agonist and muscarinic receptor modulator with neuroprotective and antidepressant activity. In addition, Blarcamesine ameliorates neurological impairment in a mouse model of Rett syndrome. |
| M28864 | PD 144418 oxalate | PD 144418 oxalate is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively). PD 144418 oxalate devoids of any significant affinity for other receptors, ion channels and enzymes. PD 144418 oxalate shows potential antipsychotic activity. |
| M27937 | σ1 Receptor antagonist-1 | σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28). σ1 Receptor antagonist-1 inhibits cell growth, arrests cell cycle at G0/G1 phase and induces apoptosis of MCF-7/ADR cells. |
| M14060 | CT1812 | CT1812 (Sigma-2 receptor antagonist 1) is an orally active and brain penetrant sigma-2 (σ-2) receptor antagonist with a Ki of 8.5 nM. |
| M10723 | Ditolylguanidine | Ditolylguanidine (1,3-Di-o-tolylguanidine) is a sigma receptor (σ1/σ2 receptor) agonist. |
| M10722 | PRE-084 hydrochloride | PRE-084 hydrochloride is a highly affinity selective σ1 agonist with an IC50 value of 44 nM in the sigma receptor detection. |
| M10721 | Dimemorfan phosphate | Dimemorfan phosphate is a potent agonist of sigma 1 receptor that is effective in suppressing cough. |
| M6496 | BD 1063 dihydrochloride | BD 1063 dihydrochloride is a selective σ1 ligand, putative antagonist. |
| M6495 | BD-1047 dihydrobromide | BD-1047 dihydrobromide is a σ1 selective antagonist. BD-1047 dihydrobromide attenuates Apomorphine-induced climbing and Phencyclidine-induced head twitches. |
| M6346 | 4-PPBP maleate | 4-PPBP maleate is a specific σ ligand, NMDA antagonist. |
| M6344 | 4-IBP | 4-IBP is a σ ligand, σ 1> σ 2. |
| M6203 | Blarcamesine hydrochloride | Blarcamesine hydrochloride is a Sigma-1 Receptor agonist with an IC50 of 860 nM. |
| M4796 | Veratramine | Veratramine (NSC17821; NSC23880) is a signal transduction inhibitor that acts on tumors. Veratramine induces autophagic apoptosis of tumor cells, arrests the cell cycle at the G0/G1 phase, and inhibits epithelial-mesenchymal transition (EMT)-related proteins to reduce tumor migration. Veratramine has anti-tumor proliferation, apoptosis induction, anti-inflammatory and neuroprotective activities. |
| M2991 | Cutamesine dihydrochloride | Cutamesine dihydrochloride (SA4503 dihydrochloride; AGY94806 dihydrochloride) is a novel and selective opioid sigma1 receptor agonist with IC50 of 17.4 nM. |
| M2924 | Pentoxyverine Citrate | Pentoxyverine citrate is an orally active sigma-1 receptor agonist with Ki values of 41 nM for σ1, 894 nM for σ2, and 75 nM for σ1 in guinea pig brain membranes.Pentoxyverine citrate is also a muscarinic antagonist. |
| M2596 | S1RA | S1RA (E-52862) is a potent and selective sigma-1 receptor (σ1R, Ki=17 nM), which showes good selectivity against σ2R (Ki > 1000 nM). |
| M2593 | Siramesine hydrochloride | Siramesine (Lu 28-179) hydrochloride is an effective sigma-2 receptor agonist. Siramesine has a nanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and is 140 times more selective for sigma-2 receptors (IC50=17 nM). Siramesine has xC-system inhibitory activity associated with iron death. |
| M2592 | Siramesine | Siramesine (Lu 28-179) is a potent sigma-2 receptor agonist. Siramesine has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM). Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. |
| M56826 | IPAG | IPAG is a potent sigma-1 receptor antagonist with a pKi of 4.3. |
| M56825 | PB28 dihydrochloride | PB28 dihydrochloride, a cyclohexylpiperazine derivative, is a high affinity and selective sigma 2 (σ2) receptor agonist with a Ki of 0.68 nM. |
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