| Cat.No. | Name | Information |
|---|---|---|
| M27835 | Bisindolylmaleimide V | Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies with an IC50 value over 100 µM. Bisindolylmaleimide V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 of 8 µM. |
| M14183 | CMK | CMK is a RSK2 kinase inhibitor which exhibits similar potency but less chemical stability compared with FMK. |
| M14182 | BIX 02565 | BIX 02565 is a potent ribosomal S6 kinase 2 (RSK2) inhibitor with IC50 of 1.1 nM. |
| M7566 | LJI308 | LJI308 is a new and potent pan-RSK inhibitor, with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. |
| M4864 | LY2584702 Tosylate | LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. |
| M4830 | LY2584702 | LY2584702 is a selective, ATP-competitive p70 S6 kinase inhibitor with IC50 of 4 nM. |
| M4384 | Quercitrin | Quercitrin (Quercitrin) is a natural compound in bitter buckwheat, which has anti-inflammatory effects and has the potential to be used in cardiovascular disease research. |
| M3200 | SL 0101-1 | SL-0101-1 is a selective p90 RSK inhibitor for RSK2 with IC50 of 89 nM. |
| M2710 | FMK | FMK is a potent and selective inhibitor of p90 ribosomal protein S6 kinaseRSK2 (wt) with IC50 of 15 nM, >600- and 200-fold selectivity for RSK2 than the C436V and T493M mutants. |
| M2271 | PF-4708671 | PF-4708671 is a novel cell-permeable inhibitor of S6K1 with Ki/IC50 value of 20 nM/160 nM. PF4708671 inhibits MSK1 (IC50 of 0.95 μM) 4-fold more weakly than S6K1. |
| M1948 | BI-D1870 | BI-D1870 is an ATP-competitive, cell permeable and brain penetrated inhibitor of the p90 RSK (ribosomal S6 kinase) with IC50 values of 31 nM, 24 nM, 18 nM, 15 nM for RSK1, RSK2, RSK3, RSK4, respectively. |
| M42157 | S6K1-IN-DG2 | S6K1-IN-DG2 is a p70S6K inhibitor (IC50: < 100 nM). |
| M30012 | BRD7389 | BRD7389 is a specific RSK family kinase inhibitor with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively. BRD7389 is a small-molecule inducer of insulin expression in pancreatic α-cells. |
| M28289 | M2698 | M2698 (MSC2363318A) is an orally active, ATP competitive, selective p70S6K and Akt dual-inhibitor with IC50s of 1 nM for p70S6K, Akt1 and Akt3. M2698 can cross the blood-brain barrier and has anti-cancer activity. |
| M20745 | S6K-18 | S6K-18 is a highly selective inhibitor of ribosomal protein S6 kinase beta-1 (S6K1, p70S6K, p70-S6K). |
| M14184 | LJH685 | LJH685 is a potent, ATP-competitive and selective RSK inhibitor, inhibits RSK1, 2, and 3 biochemical activities with IC50s of 6, 5, 4 nM, respectively. |
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