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Streptozocin (STZ) is an antineoplastic antibiotic. This N-nitroso-containing compound acts as a nitric oxide donor in pancreatic islets. It is a methylnitrosourea attached to a single molecule of glucosamine and has a high affinity for the cell surface glucose transporter glucose transporter type 2 (GLUT2), which is highly expressed on beta cells of the islets of Langerhans. Streptozocin is used in experimental animal models of induced diabetes.
Solution is extremely unstable at room temperature, and can be decomposed into gas and volatilized after half an hour, freshly prepared is recommended.
| Molecular Weight | 265.22 |
| Formula | C8H15N3O7 |
| CAS Number | 18883-66-4 |
| Solubility (25°C) | Water 90 mg/mL DMSO >100 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
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