All AbMole products are for research use only, cannot be used for human consumption.
D-GsMTx4 is the D enantiomer of GsMTx4. D-GsMTx4 inhibits the mechanosensitive ion channel Piezo2. D-GsMTx4 inhibits mTOR and PI3K-Akt signaling pathways. D-GsMTx4 inhibits [Ca2+]i elevation. D-GsMTx4 inhibits mechanical allodynia and thermal hyperalgesia.
Sequence: d-(Gly-Cys-Leu-Glu-Phe-Trp-Trp-Lys-Cys-Asn-Pro-Asn-Asp-Asp-Lys-Cys-Cys-Arg-Pro-Lys-Leu-Lys-Cys-Ser-Lys-Leu-Phe-Lys-Leu-Cys-Asn-Phe-Ser-Phe)-NH2 (Disulfide bridge:Cys2-Cys17, Cys9-Cys23, Cys16-Cys30)
| Molecular Weight | 4095.84 |
| Formula | C185H273N49O45S6 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C, protect from light, dry, sealed In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, dry, sealed) |
| Best-selling Piezo Channel Products |
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| Yoda1
Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). |
| Other Piezo Channel Products |
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| Dooku1
Dooku1 is a reversibly Yoda1 antagonist, Dooku1 is a selective antagonist of the endogenous Piezo1 channel. Dooku1 inhibits 2 μM Yoda1-induced Ca2+Incoming, IC50 values in HEK 293 cells and HUVECs are 1.3 μM and 1.5 μM, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. |
| Jedi2
Jedi2 is a Piezo1 activator, but not a specific Piezo2 activator. Jedi2 binds to the mouse Piezo1 proteins with a Kd of 2770 μM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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