Molecular Glues Molecular Glues

Cat.No.	Name	Information
M66343	ALV1	ALV1 is a molecular glue degrader for Ikaros (IKZF1) and Helios (IKZF2) with DC50 of 2.5 nM and 10.3 nM respectively. ALV1 bind CRBN with an IC50 of 0.55 μM, and induces CRBN-Helios dimerization.
M57136	dCeMM1	dCeMM1 is a RBM39 glue degrader.
M124486	IBG3	IBG3 is a dual-JQ1-containing BET degrader (molecular glue) that induces targeted degradation of BRD4 and BRD2 via intramolecular bivalent glues, with DC50 values of 6.7 pM and 8.6 pM respectively, it can be used for epigenetic reader domain research. By recruiting the DCAF16 E3 ligase, IBG3 cis-binds to the tandem bromodomains of BRD2 and BRD4, enhances BRD-DCAF16 binding affinity, promotes ubiquitination and proteasomal degradation, and does not degrade isolated bromodomains.
M57140	dCeMM3	dCeMM3 is a glue degrader.
M57137	dCeMM4	dCeMM4 is a glue degrader.
M57135	(S)-Thalidomide	(S)-Thalidomide ((S)-(-)-Thalidomide) is the S-enantiomer of Thalidomide.
M57134	HbF inducer 2	HbF inducer 3 is an orally active molecular glue, which degrades the WIZ transcription factor (DC50=13 nM in primary human erythroid precursor cell) and induces the expression of fetal hemoglobin (HbF) (EC50=100 nM).
M57133	KT-333 ammonium	KT-333 ammonium is a molecular glues that degrades STAT3 protein.
M57132	KT-333 diammonium	KT-333 diammonium is a molecular glues that degrades STAT3 protein.