| Cat.No. | Name | Information |
|---|---|---|
| M1817 | Y-27632 dihydrochloride | Y-27632 is a potent, selective inhibitor of Rho-associated protein kinases (ROCK) with IC50 values of 140-220 nM for ROCK1 and ROCK2. In addition, Y-27632 inhibited LPA-induced entosis. |
| M4839 | Cell Counting Kit-8 | Cell Counting Kit-8 (CCK-8) allows sensitive colorimetric assays for the determination of cell viability in cell proliferation and cytotoxicity assays. |
| M5293 | Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO) | Protease inhibitor cocktails are used in mammalian cell lysates or tissue extracts to increase protein stability. |
| M4881 | RNA Synthesis IN-1 | RNA Synthesis IN-1 (a substitute for Actinomycin D) is an inhibitor of RNA and protein synthesis, with antibacterial and anti-tumor effects. RNA Synthesis IN-1 can inhibit the protein synthesis of bacteria, directly bind to the guanine groups of single-stranded or double-stranded DNA in the transcriptional initiation complex, inhibit the activity of DNA-dependent RNA polymerase, and interfere with the transcription process of DNA, thereby inhibiting mRNA synthesis. RNA Synthesis IN-1 inhibits DNA repair with an IC50 value of 0.42 μM. |
| M7528 | Phosphatase Inhibitor Cocktail (EDTA-Free, 50X) | AbMole Phosphatase Inhibitor Cocktail (EDTA-Free, 50X) is a mixture of phosphatase inhibitors prepared by 8 independent phosphatase inhibitors according to the optimized ratio. It is divided into A and B two tubes: A tube is a phosphate - root analogue to prevent the loss of phosphorylation of proteins and lipids, and B tube is a new natural product to provide more comprehensive protection for phosphorylation. |
| M4879 | Protein Synthesis IN-1 | Protein Synthesis IN-1 (a substitute for Cycloheximide) is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM. Protein Synthesis IN-1 binds to the E-site of the 60S subunit of the ribosome during the protein synthesis process in eukaryotic cells, blocking the ribosome translocation process mediated by eEF2 and preventing the synthesis of new proteins. Protein Synthesis IN-1 suppresses ferroptosis and inhibits autophagy. |
| M1902 | MG132 | MG132 is a specific and potent cell-permeable proteasome inhibitor (IC50 = 100 nM, Ki = 4 nM). MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132 is also a calpain inhibitor with IC50 of 1.2 μM. |
| M1925 | LY294002 | LY294002 is a highly selective PI3K inhibitor with IC50 values of 0.31, 0.73, 1.06 and 6.60 μM for PI3Kβ, PI3Kα, PI3Kδ and PI3Kγ respectively. LY294002 also inhibits CK2 with an IC50 of 98 nM. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4 μM. LY294002 is also a Macropinocytosis/Phagocytosis inhibitor. |
| M3850 | Dimethyl sulfoxide (cell cryopresevation) | Dimethyl sulfoxide (abbreviated DMSO) is a common organic solvent which has the strongest dissolving ability, it can dissolve most of the organic compounds. |
| M5385 | Acetylcysteine (NAC) | Acetylcysteine (NAC; N-acetyl-l-cysteine) is a ROS inhibitor that antagonizes the activity of several proteasome inhibitors. It is also an inhibitor of the tumor necrosis factor TNF. |
| M9524 | Lipopolysaccharides | Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. This product is derived from Escherichia coli O55:B5. |
| M1768 | Rapamycin | Rapamycin (Sirolimus,Rapamune)is an inhibitor of mTOR.The mammalian target of rapamycin (mTOR) is a kinase responsible for mitogen-induced cell proliferation/survival signaling. |
| M4647 | Phorbol 12-myristate 13-acetate | Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and protein kinase C (PKC) activator, increases the intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner, with an EC50 of 11.7 nM. |
| M8692 | ML385 | ML385 was a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC50 of 1.9 μM. ML385 inhibits Nrf2 transcription factor activity by binding to Neh1. |
| M2698 | Ferrostatin-1 | Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. |
| M9162 | Triton X-100 | Triton X-100 is a nonionic, non-denaturing detergent suitable for solubilization, isolation and purification of membrane protein complexes. It is chemically indistinguishable from Nonidet P-40. |
| M2296 | 3-Methyladenine (3-MA) | 3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM, respectively. |
| M2082 | Stzocin | Streptozotocin (Streptozocin; STZ; Stzocin) is an antibiotic widely used in experimental animal models of induced diabetes. Streptozotocin enters B cells via the glucose transporter (GLUT2) and causes the alkylation of DNA ( DNA-methylating ). Streptozotocin can induce the apoptosis of β cells. *The compound is unstable in solutions, freshly prepared is recommended |
| M9096 | H2DCFDA | H2DCFDA is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) (Ex/Em=488/525 nm). H2DCFDA can be used for the Bacterial reactive oxygen species (ROS) production assay. |
| M1837 | MK-2206 2HCl | MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. |
| M3143 | Z-VAD-FMK | Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor which blocks all features of apoptosis. |
| M5106 | DAPI dihydrochloride | DAPI dihydrochloride is A fluorescent dye that binds DNA rich in a-T sequences. The maximum excitation/emission wavelength is 358nm/461 nm, and the blue fluorescence is often used to observe the nucleus and nucleic acid. Store at room temperature away from light. |
| M2129 | Temozolomide | Temozolomide (TMZ) is an oral DNA methylating, chemotherapeutic agent. |
| M2238 | Dorsomorphin dihydrochloride | Dorsomorphin (BML-275; Compound C) dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK), with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride induces autophagy. |
| M2223 | CDDP | Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells. |
| M8873 | D-Luciferin potassium salt (Ultra pure) | D-Luciferin potassium salt is the natural specific substrate for firefly luciferase (FLuc) and one of the most commonly used dyes in bioluminescence and in vivo imaging experiments. D-Luciferin potassium salt is catalysed by FLuc into luciferin in the presence of ATP, magnesium ions, and oxygen, emitting fluorescence with a peak wavelength of approximately 560 nm. In experiments, by integrating the FLuc gene as a reporter element into target cells (such as tumour cells, stem cells, or pathogenic microorganisms) or transgenic animals, followed by intraperitoneal or intravenous injection of D-luciferin potassium salt, real-time, non-invasive tracking and quantitative analysis of these targets can be achieved using imaging equipment. |
| M1692 | CHIR-99021 | CHIR-99021 (CT99021) is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively. |
| M5107 | DAPI solution | |
| M6164 | MCC950 | MCC950 (CP-456773) is a potent, selective NLRP3 inhibitor with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively. |
| M5112 | Hoechst 33342 | Hoechst 33342 (HOE 33342) is a cell membrane permeable nuclear staining reagent for DNA staining. The maximum excitation/emission wavelength is 361nm/497nm, and it gives blue fluorescence, which is often used to observe the nucleus/nucleolus. Store at 4°C away from light. |
| M1977 | U0126-EtOH | U0126-EtOH is a potent and highly selective non-competitive inhibitor of MAPK/ERK kinase with IC50 of 72 nM for MEK1 and 58 nM for MEK2. |
| M4838 | TAK-242 (Resatorvid) | Resatorvid (TAK-242) is a selective TLR4 signaling inhibitor. Resatorvid inhibited the production of NO, TNF-α and IL-6 with IC50 values of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid down-regulates the expression of MyD88 and TRIF signaling molecules downstream of TLR4. Resatorvid inhibits autophagy and plays a key role in a variety of inflammatory diseases. |
| M2679 | Erastin | Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. *The compound is unstable in solutions, it must be prepared freshly and used immediately. |
| M2076 | SP600125 | SP600125 is a novel and selective inhibitor of c-Jun N-terminal kinase (JNK), inhibited phosphorylation of c-Jun with an IC50 of 5-10 microM. |
| M8083 | MCC950 sodium salt (CP-456773) | MCC950 (CP-456773) sodium salt is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. MCC950 specifically inhibits NLRP3 but not AIM2, NLRC4 or NLRP1 activation. |
| M1820 | Tofacitinib | Tofacitinib (formerly tasocitinib, CP-690550) is a novel Janus Kinase 3 (JAK-3) kinase inhibitor with an IC50 value estimated at 0.2 μM. |
| M6033 | Dihydrotestosterone | Dihydrotestosterone is an androgen (male hormone). Specifically it's the strongest of the androgens. It can be used to construct animal models of polycystic ovary syndrome (PCOS). |
| M4005 | PDTC | Pyrrolidinedithiocarbamate ammonium (PDTC) is a selective and blood-brain barrier (BBB) permeable nuclear factor-κB (NF-κB) inhibitor. |
| M14788 | MS-222 | Tricaine methanesulfonate (MS-222) is common used to immobilize fish for marking or transport and to suppress sensory systems during invasive procedures. |
| M3637 | Puromycin dihydrochloride | Puromycin dihydrochloride is an aminonucleoside antibiotic that acts as a protein synthesis inhibitor. |
| M5791 | DNA Synthesis IN-1 | Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis. Mitomycin C (Ametycine) is a DNA cross-linking agent and induces DNA damaging. Mitomycin C is an ADC Cytotoxin and induces apoptosis. |
| M1732 | Talazoparib | Talazoparib (BMN-673) is a highly potent, orally active PARP1/2 inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with Kis of 1.2 nM and 0.87 nM, respectively. Talazoparib has antitumor activity. |
| M2952 | PMSF | PMSF is an irreversible serine/cysteine protease inhibitor. PMSF is commonly used in the preparation of cell lysates. |
| M2176 | Dexamethasone | Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist that induces the production of phospholipase A2 inhibitory protein.It can be used to construct models of allergic conjunctivitis. |
| M5037 | A 83-01 | A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively).*The compound is unstable in solutions, freshly prepared is recommended |
| M13565 | Hoechst 33342 trihydrochloride | Hoechst 33342 trihydrochloride is a membrane permeant blue fluorescent DNA stain. Hoechst binds to the grooves in the DNA double strand, which tends to be A/T-rich DNA strand. Although it binds to all nucleic acids, the A/T-rich double strand DNA significantly enhances fluorescence intensity Therefore, Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution. |
| M1664 | AZD2281 (Olaparib) | AZD 2281 (Olaparib, KU-0059436) is a potent PARP (poly ADP-ribose polymerase) inhibitorwith IC50 of 5 and 1 nM for PARP-1and PARP-2 respectively. Olaparib is an autophagy and mitophagy activator. |
| M1796 | XAV939 | XAV939 is a potent, cell-permeable small molecule inhibitor of the Wnt/β-catenin pathway to TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively. |
| M9559 | Chloroquine | Chloroquine is an inhibitor of autophagy and Toll-like receptors (TLRs). Chloroquine can effectively inhibit SARS-COV-2 infection (EC50=1.13 μM). Chloroquine is an anti-inflammatory widely used in malaria and rheumatoid arthritis. |
| M5117 | CFDA-SE | Succinimide (CFSE) is a luciferase - based tracer that penetrates and immobilizes cells for extremely long-term cell labeling. The maximum excitation/emission wavelength is 494nm/521 nm. Fluorescent green. Store away from light. |
| M1781 | Adezmapimod | Adezmapimod (SB203580) is a P38 MAPK inhibitor with an IC50 of 0.3-0.5 μM, which is 10 times less selective than SAPK3(106T) and SAPK4(106T), and inhibits PKB phosphorylation with an IC50 of 3-5 μM. |
| M5558 | Deferoxamine mesylate | Deferoxamine mesylate is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine mesylate upregulates HIF-1α levels with good antioxidant activity. Deferoxamine mesylate also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine mesylate acts as a chelating agent used to remove excess iron from the body. |
| M4947 | Streptomycin sulfate | Streptomycin sulfate is an antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis. |
| M6793 | HEPES | HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is a multipurpose buffer. |
| M9049 | MPTP hydrochloride | MPTP hydrochloride is dehydrogenated in nigrostriatal cells to generate MPP+, which in turn inhibits mitochondrial complex enzymes and contributes to cell death. MPTP hydrochloride can be used to construct animal models of Parkinson's disease. |
| M9443 | Dextran sulfate sodium salt | Dextran sulfate sodium salt is a polyanionic derivative of dextran produced by esterification of Dextran with chlorosulphonic acid. |
| M1753 | Trichostatin A | Trichostatin A (TSA) is a potent and specific inhibitor of mammalian histone deacetylase (HDAC) class I/II, with an IC50 value of 1.8 nM for HDAC. |
| M1763 | Mirdametinib | Mirdametinib (PD0325901) is a highly potent and selective MEK inhibitor with an IC50 in C26 cells of 0.33nM. |
| M1759 | GSK1120212 (Trametinib) | Trametinib (GSK1120212; Jtp-74057) is an orally effective MEK inhibitor with IC50 of 2 nM against MEK1 and MEK2, respectively. Trametinib can activate autophagy and induce apoptosis. |
| M1822 | PD98059 | PD98059 is a potent and selective inhibitor of mitogen-activated protein kinase kinase (MKK / MEK) with IC50 value of 2-7 μM. The expression of KAT2B protein in cells is significantly decreased after PD98059 inhibits ERK signaling pathway. |
| M2084 | SCH772984 | SCH772984 is a novel and selective inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. |
| M5868 | Penicillin G Sodium | Penicillin G Sodium is a β-lactam antibiotic produced by Penicillin spp. |
| M4837 | SBE-β-CD | SBE-β-CD (Sulfobutylether beta-cyclodextrin) is a unique reproducible mixture of polyanionic β-cyclodextrin derivatives in which a sodium sulfonate salt is tethered to the lipophilic cyclodextrin cavity by a butyl ether group, or sulfobutylether (SBE). |
| M2081 | LY2109761 | LY2109761 is a novel TGF-β receptor type I and type II dual inhibitor, with Ki values of 38 nM and 300 nM, respectively. |
| M1969 | Doxorubicin HCL | Doxorubicin HCl (Adriamycin, DOX, RP 13057) hydrochloride is an antibiotic-like agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis. |
| M3621 | Ionomycin | Ionomycin is a calcium ionophor and an antibiotic produced by Streptomyces conglobatus. |
| M3946 | BML-275 | BML-275 (Dorsomorphin) is a cell-permeable pyrazolopyrimidine compound shown to be an AMPK inhibitor with Ki of 109 nM in cell-free assays. |
| M6327 | 2-NBDG | 2-NBDG is a fluorescently-labeled deoxyglucose analog that is used primarily to directly monitor glucose uptake by living cells and tissues. 2-NBDG can be used in real-time confocal, high-resolution, or wide-field fluorescence microscopy as well as in flow cytometry. The probe can be excited by the Argon laser at 488 nm to give the environment-sensitive fluorescence. |
| M7727 | CH-223191 | CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM. *The compound is unstable in solutions, freshly prepared is recommended |
| M9850 | ABDP 493/503 | ABDP 493/503 (same as BODIPY 493/503) is a lipophilic fluorescent probe that localizes to polar lipids and can be used to label cellular neutral lipid contents, particularly those localized to lipid droplets, in live and fixed cells. |
| M1712 | FTY720 hydrochloride | Fingolimod (FTY720) HCl is a 1-phospho-neuraminol S1P receptor antagonist with an IC50 of 0.33 nM. , FTY720 can dephosphorylate AMPK by activating PP2A and reduce the expression level of phosphorylated eEF2K, ultimately leading to ADCD and iron death in human multiple myeloma cells. |
| M9638 | 4-Phenylbutyric acid (4-PBA) | 4-Phenylbutyric acid is an inhibitor of HDAC, inhibits the growth of NSCLC Cell Lines at 2 mM. |
| M5122 | DiR iodide | DiR is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins. |
| M2062 | SB 202190 | SB 202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinase with IC50 values of 50 and 100 nM inhibiting p38α and p38β, respectively. |
| M2315 | Necrostatin-1 | Necrostatin-1 (NEC-1) is a potent inhibitor of necroptosis, with an EC50 of 490 nM in Jurkat cells. Necrostin-1 is the first identified RIPK1 inhibitor, EC50=182 nM, that reduces inflammation and inhibits colitis associated tumorigenesis. Necrostatin-1 (Nec-1) is also an inhibitor of IDO. |
| M4798 | Tunicamycin | Tunicamycin is a mixture of nucleoside antibiotics that inhibits N-glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin can cause the accumulation of unfolded proteins within the endoplasmic reticulum (ER) and induce ER stress, leading to impaired DNA synthesis and G1 phase cell cycle arrest. |
| M2569 | Dynasore | Dynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM. Dynasore is also a Clathrin-Mediated Endocytosis (CME) inhibitor. |
| M3241 | Imatinib | Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively. |
| M1646 | AG490 | AG490 (Tyrphostin AG490) is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). |
| M2017 | ABT-199 | ABT-199 (Venetoclax) is a highly potent, orally bioavailable and BCL-2 inhibitor. ABT-199 is the first inhibitor targeting Bcl-2 and PPI. |
| M2292 | Cytarabine | Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM. |
| M1708 | Selisistat | Selisistat (EX 527) is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 98 nM. |
| M1746 | DAPT | DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively. DAPT inhibits the activation of Notch 1 signaling. |
| M1787 | INCB18424 | Ruxolitinib (INCB018424) is a first-in-class, potent, selective JAK1/2 inhibitor with an IC50 of 3.3 nM/2.8 nM. It is more than 130-fold more selective for JAK1, JAK2, and JAK3 than JAK3. It can be used in studies related to pemphigus, myelofibrosis and vitiligo. |
| M5114 | Calcein-AM | Calcein-am is a fluorescent dye that penetrates cells and is used to measure cell viability. The excitation and emission wavelengths of Calcein are 494 nm and 517 nm, respectively. Fluorescent green. Store at -20℃ away from light. |
| M1831 | Cyclosporine A | Cyclosporine A (CsA，Cyclosporin A) is an immunosuppressant that binds to cyclophilin and inhibits calcineurin with an IC50 of 7 nM. Cyclosporine A [CsA] binds to the cyclophilin 18 (Cyp18)-CsA complex. the Cyp18-CsA complex recruits calcium-regulated neurophosphatase (CaN), leading to the blocking of cytokine gene transcription in activated T cells. CsA is a highly specific inhibitor of T-cell activation. |
| M2066 | Staurosporine | Staurosporine (AM-2282) is a potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively. |
| M1966 | Fulvestrant | Fulvestrant is a Estrogen receptor (ER) antagonist with IC50 of 0.094 nM. Fulvestrant can also induce autophagy and apoptosis, and has anti-tumor effect. |
| M9060 | RSL3 | RSL3 is an inhibitor of the glutathione (GSH) peroxidase 4, and a ferroptosis activator, which can inhibit the cysteine/glutamate amino acid transporter system. |
| M1970 | Paclitaxel | Paclitaxel is a diterpenoid derived from the bark of the plant Picea abies, and is also a microtubule polymer stabilizer, which promotes polymerization of microtubule proteins to inhibit depolymerization, maintains the stability of microtubule proteins, and inhibits cellular mitosis, and acts on human endothelial cells with an IC50 of 0.1 pM. |
| M5140 | 2-Deoxy-D-glucose | 2-Deoxy-D-Glucose (2-DG) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which cannot be further metabolized by phosphoglucose isomerase. |
| M9391 | Recombinant Human TGF-β1 (CHO) | Recombinant Human TGF-β1 regulates cell proliferation, growth, differentiation and cells movement. TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. |
| M1894 | Rosiglitazone | Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC50=60 nM, Kd=40 nM). Rosiglitazone is an TRPC5 activator (EC50=30 μM) and TRPM3 inhibitor. |
| M2040 | BAY 11-7082 | BAY 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation (IC50 ~ 10 μM). BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). |
| M2326 | Etoposide | Etoposide (VP-16-213) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. |
| M9194 | Insulin (human) | Insulin (human) is a polypeptide hormone that regulates the level of sugar (glucose) in the blood and is produced by beta cells of islets. |
| M1715 | GDC-0941 (Pictilisib) | GDC-0941 is a selective and potent inhibitor of Class I PI3K, p110a IC50=0.003uM, U87MG IC50=0.95μM. |
| M4896 | Nicotinamide | Nicotinamide is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins. Nicotinamide plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. |
| M2052 | Decitabine | Decitabine (5-Aza-2'-deoxycytidine) is a potent inhibitor of DNA methylation for the treatment of myelodysplastic syndromes. |
| M2191 | Forskolin | Forskolin is a diterpenoid natural product extracted from the hairy throat sphagnum flower (Coleus forskohlii), and is also a eukaryotic adenylate cyclase (AC) activator, which can increase cAMP levels. In addition, Forskolin can be used as a substitute for Oct4 in the induction and maintenance of pluripotent stem cells in mice and promotes osteoblast differentiation in vitro with potential anti-osteoporotic activity. |
| M7029 | Nigericin sodium salt | Nigericin (NSC 292567) sodium salt is a selective K+ ionophore, Nigericin sodium salt is also an NLRP3 activator which can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes. |
| M4973 | BAPTA-AM | BAPTA-AM is a selective, membrane-permeable calcium chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively. |
| M1686 | Bortezomib (PS-341) | Bortezomib (PS-341) is a highly selective proteasome inhibitor with a ki value of 6nM. |
| M2167 | (+)-JQ1 | (+)-JQ1 is a BET bromodomain inhibitor that acts on BRD4(2) with an IC50 of 33 nM and binds to all bromodomain domains in the BET family, but not to bromodomain domains outside the BET family. JQ1 down-regulates CD47 expression through a C-MYC-mediated pathway, and JQ1 down-regulates CD47 expression through a C-MYC-mediated pathway. |
| M9317 | Carboxymethyl cellulose sodium | Carboxymethyl cellulose sodium is frequently used as viscous agent, paste and barrier agent. |
| M9050 | MHY1485 | MHY1485 is an mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes. |
| M4953 | Bafilomycin A1 | Bafilomycin A1 (BafA1) is a vacuolar H+-ATPase inhibitor with IC50 of 0.44 nM. |
| M6240 | Angiotensin II human | Angiotensin II human is converted by Angiotensin I through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE). Angiotensin II is mediated by AT1 and AT2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity. Keep away from light and prepare for use now. |
| M6105 | Testosterone | Testosterone is a modulator of the androgen receptor (AR). When the intracellular metabolites of testosterone bind to the AR, they induce a conformational change in the receptor, causing it to translocate from the cytoplasm into the nucleus. There, it binds to the androgen response element (ARE) on DNA, thereby regulating gene transcription. In experimental studies, testosterone is frequently employed to investigate cellular differentiation, construct organoids, and explore its regulatory roles in muscle growth, bone density maintenance, haematopoietic function, and cognitive behaviour. |
| M5109 | PI solution | Propidium Iodide is a red-fluorescent dye that can be used to stain cells. |
| M2830 | Mdivi-1 | Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. |
| M1749 | Gefitinib | Gefitinib (ZD1839) is an EGFR tyrosine kinase and Akt phosphorylation inhibitor. Gefitinib significantly down-regulates CD47 expression and increases DC phagocytosis in non-small cell lung cancer cells such as PC9, H1437 and H1573. Gefitinib combined with CD47 antibody can enhance the phagocytosis of macrophages. |
| M3532 | Belnacasan | Belnacasan (VX-765) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM. |
| M3422 | Capsaicin | Capsaicin is an active component of chili peppers, which are plants belonging to the genus Capsicum. |
| M9109 | Corn oil | Corn oil, extracted from the germ of corn, can be used as a carrier for drug molecules and has anti-tumor activity. It can be used to construct animal models of hypospadias. |
| M1637 | ABT-263 | ABT-263 (Navitoclax) is a potent, orally bioavailable inhibitor of the antiapoptotic Bcl-2 family members Bcl-2, Bcl-x (L), and Bcl-w. |
| M10272 | Fluorescein Sodium | Fluorescein Sodium is a phthalic indicator dye used as a diagnostic aid in corneal injuries and corneal trauma. |
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